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LOVD v.2.0 - Leiden Open Variation Database
Online gene-centered collection and display of DNA variants
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Please note that LOVD2 is no longer supported. The last security release is from October 2020. Upgrade to LOVD3 to continue receiving updates. |
LOVD Scripts
Reading Frame Checker
The Reading Frame Checker allows you to to quickly generate a prediction of the effect of whole-exon deletions and duplications on the RNA translation. Amongst others, the script will check if the given deletion or duplication is in-frame or out-of-frame. It will also generate the HGVS name of the given mutation.
The Reading Frame Checker is only available for your gene database if you have once run the Reference Sequence Parser, because the Checker needs to know exon and intron information from your gene that the Reference Sequence Parser takes out of the GenBank file. Once available, it is also linked to from the gene homepage, in the "Graphical displays and utilities" table.
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This feature was added in LOVD 2.0-22, released 2009-10-05. |
| Last modified 2014/08/25 14:48:31 CEST |
When using or discussing LOVD please refer to:
Fokkema IF, Taschner PE, Schaafsma GC, Celli J, Laros JF, den Dunnen JT (2011). LOVD v.2.0: the next generation in gene variant databases.
Hum Mutat. 2011 May;32(5):557-63.
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